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| Id: | 18826
| | Autor: | Convit, Jacinto; Monzón, H; Pinardi, M. E; Aránzazu, N; Ulrich, M
| | Título: | The development of an active vaccine against leprosy
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| | Fonte: | s.l; s.n; 1979. 3 p. .
| | Resumo: | The development of an effective vaccine against leprosy will be directed to obtain a product which can modify the immunological response of the population susceptible to develop the disease and to avoid the occurence of lepromatous, infecting forms. This action would interrupt the transmission chain, producing a important decrease in tge incidence of the disease. The measures used at present fotr anti-leprosy campaigns such as early diagnosis, control of contacts, out-patient treatment and prevention of disabilities, can be effective if applied with a high degree of efficiency and during extended periods of time. If to these measures we could add a vaccine, we would be able to reduce considerably the expense and time needes for keeping the disease under control. The development of a vaccine against leprosy is based on the assumption the disease is due to an immunological defect of the host which is specific against this particular bacterium. Previous work done by us, where we have obtained highly favorable immunological modifications in pre-lepromatous, indeterminate patients and in Mitsuda negative contacts and, partially, in lepromatous patients, using an injection of a mixture of armadillo M. leprae and BCG, serves as basis for our proposal of using this same type of preparation as an anti-leprosy vaccine in susceptible persons, where ity would evoke a positive immunological change which would prevent the onset of infecting forms of the disease.(AU).
| | Descritores: | VACINAS BACTERIANAS/admin
HANSENIASE/imunol
HANSENIASE/prev
MYCOBACTERIUM LEPRAE/imunol
VENEZUELA
| | Limites: | HUMANO
| | Meio Eletrônico: | - .
| | Localização: | BR191.1; 00575/s |
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